Greeters and Admins needed for Mobile flu Clinic
posted: August 19, 2010, 03:05 PM

PUSH MODELS!!!!

Promotional Modeling Agency looking to hire Brand Ambassadors for an upcoming 6 week program. We are staffing a Mobile Flu Clinic that will be in Bangor Mall in Bangor, ME. We need outgoing, attractive, enthusiastic, and intelligent guys or girls between the ages of 18-30.

This is also a great opportunity for advancement in doing more promotional work. This program will run for 6 consecutive weekends (Saturdays and Sundays only). We are booking ambassadors for all 6 weekends, or every other weekend.

Please apply online at www.pushmodels.com. After you have filled out your profile, please email Amber Gordon at ag@pushmodels.com, put "Mobile Flu Clinic" in subject line, and specify that you will work in Bangor, ME.
Salary/Wage: $12/hr
Shift: Weekends

• Location: Bangor

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Autism Speaks

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BBB Wise Giving Report expires September 2011

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cid:_1_0E51C98C0E51C4D00074D2AC8825777D
OFFICE OF PUBLIC AFFAIRS
1250 BELLFLOWER BLVD. * LONG BEACH, CALIFORNIA 90840-0116 * 562/985-4134 FAX 562/985-8109

PRESS RELEASE



FOR IMMEDIATE RELEASE
August 12, 2010
F2010-024


Cal State Long Beach Biochemist's Research Supports Premise That
Chemical Plasticizers May Contribute to Autism and Alzheimer's Disease



Who knew that brine shrimp—the tiny creatures popularly known as “Sea-Monkeys”—could reveal problems with chemicals found in plastics or even contribute to potential treatments for neurological conditions such as Alzheimer’s disease and autism?

Roger Acey, a professor of biochemistry at California State University, Long Beach (CSULB), and students in his lab have been studying the biology and genetics of embryonic development, using brine shrimp, Artemia salina, as a biological model. He is particularly interested in how environmental contaminants affect development.

“I think all baby boomers understand Sea-Monkeys,” Acey explained. “As kids, you could order them from suppliers advertising in comic books and grow them at home.” Artemia have long been used in scientific research and remain popular in science education at school and home. The shrimp grow up to three-quarters of an inch long and can live for some time once hatched.

Acey’s lab initially looked at how exposing the shrimp to toxic metals like copper, mercury, cadmium, etc., could affect their development. While continuing this successful work, which led to discovery of a shrimp protein that can capture metals, Acey took his ongoing research with Artemia in another direction.

“We began looking at plasticizers and how they might affect embryonic development,” he said. “We started looking at phthalate esters—compounds that give plastic bottles their malleability. They’re found in PVC (polyvinyl chloride), blood bags, plastic tubing, cosmetics and children’s toys, and are well known environmental contaminants. They have been reported to be teratogens (causing birth defects), carcinogens and endocrine disruptors. Endocrine disruptors are compounds that resemble the structure of estrogens and mimic the activity of these hormones. There are examples of populations of fish that are essentially all female due to phthalate ester contamination. Most recently, phthalate esters have been implicated in Type II diabetes.

“We made a series of phthalate esters (phthalates) with increasing the carbon chain lengths and started looking at the effect of these compounds on developing shrimp,” he continued. “Diethyl and dimethyl are non-toxic; di-n-propyl was slightly toxic; but di-n-butyl (DBP), which is the most commonly found phthalate, turns out to be the most toxic.”

As the shrimp develop, they produce an enzyme that metabolizes the DBP, he said. “At first, we called the enzyme DBPase. As soon as the shrimp hatch and begin to develop, DPBase activity increases dramatically. If you expose the shrimp to phthalate during the early period of development, they died. If you expose the shrimp to the phthalate later in development, the compound is no longer toxic. The idea is that there is a well-defined period of development when the embryos are sensitive to the phthalate. Therefore, we began looking for a specific biochemical event that was impacted by the DBP.” He has since identified DBPase as butyrylcholinesterase.

He noted that the shrimp were being affected by DBP at the point where their nervous system was beginning to develop, adding that shrimp have a cholinergic nervous system similar to humans in that they both use a chemical neurotransmitter called acetylcholine.

He and his students have since used umbilical cord stem cells to study the role of butyrylcholinesterase in developing neurons and the effect of DBP. “After the stem cells are activated and begin to develop into a neuron, the DBP becomes toxic. We think what is happening is that the DBP prevents the butyrylcholinesterase from performing its normal biological function. We’re currently in the process of determining the exact function of the enzyme," Acey said.

Acey is interested in how plasticizers might be connected to the dramatic rise in autism and Alzheimer’s disease. A recent study has shown that rat fetuses exposed to DBP develop symptoms characteristic of autism. "If you think about it, this suggests compounds that interact with butyrylcholinesterase could induce neurological problems,” he said.

That led him to consider another plasticizer, bisphenol A, commonly called BPA, which is being widely studied for its possible toxicity. Acey’s group has shown that BPA is an inhibitor of butyrylcholinesterase. “Again, the concern is that since this compound interacts with butyrylcholinesterase, it may have a pronounced effect on neuron development,” he said. Acey believes every effort should be made to prevent exposure of pregnant women and infants to these types of compounds.

“Interestingly, the level of brain butyrylcholinesterase is significantly increased in Alzheimer’s patients,” he said. Current therapeutics used in the treatment of Alzheimer’s disease target butyrylcholinesterase, so he and CSULB Professor Ken Nakayama are collaborating on further examining the biochemistry of this enzyme and its possible connections to Alzheimer’s disease.

“Dr. Nakayama, an organic chemist, had a series of compounds he wanted tested on an enzyme from bacteria,” Acey said. “I suggested we test his compounds on butyrylcholinesterase. The results of the experiments revealed that the compounds are potent inhibitors of butyrylcholinesterase and, as such, are potential therapeutics for the treatment of Alzheimer’s disease. Alzheimer’s patients lose their cognitive functions as a result of the decrease in the level of a specific neurotransmitter. Compounds that inhibit butyrylcholinesterase result in an increase in the level of neurotransmitters —the compounds responsible for memory— and the patients begin to recover their memory.”

They’ve applied for a patent for the compounds and are preparing to write a grant proposal to fund further studies to demonstrate whether the compounds can cross the blood-brain barrier. Acey remarked that some autistic children are responding to certain Alzheimer’s drugs, so the hope is that these compounds might someday be the basis for new medications to treat both conditions.

Acey’s research has been funded by grants from CSULB, the March of Dimes, the National Institutes of Health, and the California State University Program for Education and Research in Biotechnology (CSUPERB).

To learn more about Acey’s research, visit http://chemistry.csulb.edu/roger-acey.html.

Pediatr Infect Dis J. 2010 Aug 3. [Epub ahead of print]
ADVERSE NEUROLOGIC REACTIONS AFTER BOTH DOSES OF PANDEMIC H1N1 INFLUENZA VACCINE WITH OPTIC NEURITIS AND DEMYELINATION.

Lapphra K, Huh L, Scheifele DW.

From the *Vaccine Evaluation Center, Department of Pediatrics, British Columbia Children' Hospital, University of British Columbia, Vancouver, British Columbia, Canada; and daggerDivision of Neurology, Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Abstract

When a neurologic condition develops after vaccination of a patient, the causal relationship is difficult to determine. We report an unusual case in which neurologic signs occurred in a previously healthy child after both doses of H1N1 2009 influenza vaccine, culminating in bilateral optic neuritis and disseminated encephalomyelitis. A causal association is more likely with repeated injury following influenza vaccination.

PMID: 20686434 [PubMed - as supplied by publisher]

In a lovely ironic touch, the conference hall is only a few steps from the Ferris wheel in the Orson Welles film noir classic set in postwar Vienna, “The Third Man.” On it, a cynical dealer of counterfeit drugs tells his pursuer to look down at the people below and says: “Victims? Don’t be melodramatic.... Would you really feel any pity if one of those dots stopped moving forever?”

Service Will Incinerate Unused H1N1 Vaccine
Jul 23, 2010

Clean Harbors, based in Norwell, Mass., is offering the service to health care providers because multiple doses of the vaccine contain enough mercury-based Thimerosal to be treated as a hazardous waste.

Clean Harbors of Norwell, Mass., now offers H1N1 Vaccination Incineration Services that will profile, collect, and dispose of unused 2009 H1N1 vaccine for health care customers nationwide. Multiple doses of the vaccine contain enough mercury-based Thimerosal to be treated by EPA as a hazardous waste and will be incinerated. Vaccine dated at the end of 2008 and early 2009 is now at the end of its shelf life and must be disposed, according to the company.

The HHS declaration of a 2009 H1N1 Public Health Emergency expired on June 23.

"We have seen many customers in various states looking for our H1N1 disposal capabilities," John C. Kelsey, the company's vice president, Healthcare Services, said in a July 22 e-mailed reply to questions about the service. "We wanted to announce it to the larger community as we are growing our customer count related to Healthcare Services. We have done a good amount of work in this area with vaccines through our hospital Pharmaceutical Waste programs."

He said the cost varies but is "generally the same pricing as other materials requiring hazardous waste incineration. The vaccine doses are in inventory and will be shipped via DOT packages for proper disposal," Kelsey added. "We are seeing multiple truckloads per week of the vaccine now and cannot align total amounts but we do expect the need to occur from many locations as the normal pathway for outdated items."
OLFA North America

Unused vaccine doses normally are returned through Reverse Distributors, but these have no value and thus must be disposed as a waste, he said, continuing, "It is good that PHER funds can be used to reimburse organizations for the disposal process."

CDC mandates proper disposal of H1N1 vaccines and allows Public Health Emergency Response (PHER) funds to be available for the disposal. Health care providers interested in the service can call 888-304-7035, e-mail healthcareservices@cleanharbors.com, or visit www.cleanharbors.com/healthcare.